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Prior experience, antioxidants, and mitochondrial cofactors improve cognitive function in aged beagles
Extensive spatial training does not negate age differences in response latency
Response latency in Canis familiaris: mental ability or mental strategy?
Locomotor activity rhythms in dogs vary with age and cognitive status
Size and reversal learning in the beagle dog as a measure of executive function and inhibitory control in aging
Frontal lobe volume, function, and beta-amyloid pathology in a canine model of aging
Learning ability in aged beagle dogs is preserved by behavioral enrichment and dietary fortification: a two-year longitudinal study
Cognitive experience and its effect on age-dependent cognitive decline in beagle dogs
Delivery of recombinant gene product to canine brain with the use of microencapsulation
Oxidative damage increases with age in a canine model of human brain aging
Dietary enrichment counteracts age-associated cognitive dysfunction in canines
Age-dependent decline in locomotor activity in dogs is environment specific
Visuospatial impairments in aged canines (Canis familiaris): the role of cognitive-behavioral flexibility
Neuroprotective effects of cognitive enrichment
Long-term treatment with antioxidants and a program of behavioral enrichment reduces age-dependent impairment in discrimination and reversal learning in beagle dogs
Effect of age and level of cognitive function on spontaneous and exploratory behaviors in the beagle dog
Comparison of the effects of adrafinil, propentofylline, and nicergoline on behavior in aged dogs
Ultrastructural evidence of fibrillar beta-amyloid associated with neuronal membranes in behaviorally characterized aged dog brains
Initiation and propagation of molecular cascades in human brain aging: insight from the canine model to promote successful aging
Ultrastructural analyses of beta-amyloid in the aged dog brain: neuronal beta-amyloid is localized to the plasma membrane
Behavioral activating effects of adrafinil in aged canines
Development of a protocol for studying object recognition memory in the dog
Region-specific age at onset of beta-amyloid in dogs
Oral administration of adrafinil improves discrimination learning in aged beagle dogs
A comparison of egocentric and allocentric age-dependent spatial learning in the beagle dog
Dose-specific effects of scopolamine on canine cognition: impairment of visuospatial memory, but not visuospatial discrimination
Landmark discrimination learning in the dog: effects of age, an antioxidant fortified food, and cognitive strategy
Landmark discrimination learning in the dog
Adrafinil: effects on behavior and cognition in aged canines
Magnetic resonance imaging of anatomic and vascular characteristics in a canine model of human aging
Visual-discrimination learning ability and beta-amyloid accumulation in the dog
Molecular dating of senile plaques in the brains of individuals with Down syndrome and in aged dogs
The progression of beta-amyloid deposition in the frontal cortex of the aged canine
Beta-amyloid accumulation correlates with cognitive dysfunction in the aged canine
Insights into Abeta and presenilin from a canine model of human brain aging
Canine cognition, aging and neuropathology. Introduction
Immunization with fibrillar Abeta(1-42) in young and aged canines: Antibody generation and characteristics, and effects on CSF and brain Abeta
The canine model of human cognitive aging and dementia: pharmacological validity of the model for assessment of human cognitive-enhancing drugs
Brain aging in the canine: a diet enriched in antioxidants reduces cognitive dysfunction
The canine as a model of human cognitive aging: recent developments
Further evidence for the cholinergic hypothesis of aging and dementia from the canine model of aging
Open field activity and human interaction as a function of age and breed in dogs
Use of a delayed non-matching to position task to model age-dependent cognitive decline in the dog
Effects of age on measures of complex working memory span in the beagle dog (Canis familiaris) using two versions of a spatial list learning paradigm
Spatial learning and memory as a function of age in the dog
Therapeutic actions of L-deprenyl in dogs: a model of human brain aging
Visuospatial function in the beagle dog: an early marker of cognitive decline in a model of human aging and dementia
Canine cognitive dysfunction as a model for human age-related cognitive decline, dementia and Alzheimer's disease: clinical presentation, cognitive testing, pathology and response to 1-deprenyl therapy
Effects of chronic oral administration of L-deprenyl in the dog
Cognitive functions and aging in the dog: acquisition of nonspatial visual tasks
(-)Deprenyl increases activities of superoxide dismutase (SOD) in striatum of dog brain
Effects of L-deprenyl on manifestations of aging in the rat and dog
The effect of L-deprenyl on behavior, cognitive function, and biogenic amines in the dog
The canine as an animal model of human aging and dementia
Beta-amyloid accumulation in aged canine brain: a model of early plaque formation in Alzheimer's disease
Changes in spontaneous behavior in the dog following oral administration of L-deprenyl
Research
Why use dogs?
Can we develop interventions that affect cognitive aging?
Dog in test box
Dog on box
Dog taking test
Dog on floor